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Quercetin inhibited CD38 NADase activity and ADP-ribosyl-cyclase activity with an IC 50 of 13.8 2.1 mol/L and 15.6 3.5 mol/L, respectively

The results forced a candid reassessment of the peptide's translational potential

The authors noted NNMT overexpression in many human malignancies and described 5-Amino-1MQ as a novel NNMT inhibitor with promising results across obesity and cancer cell research models